Article
Nucleotide changes related to hepatocellular carcinoma in the enhancer 1/x-promoter of hepatitis B virus subgenotype C2 in cirrhotic patients.
Cancer science - 1 Aug 2010
Cho Eun-Young, Kim Haak-Cheoul, Choi Chang-Soo, Shin Sae Ron, Park Channy, So Hong-Seob, Kim Hyung Jin, Park Raekil, Cho Ji Hyun, Moon Hyung Bae
Abstract excerpt
Hepatocellular carcinoma (HCC) is widely known to develop more frequently in cirrhotic patients with a high expression of Hepatitis B virus X protein (HBx), which is controlled by the enhancer 1 (Enh1)/X-promoter. To examine the effect of the mutations in the Enh1/X-promoter region in hepatitis B...
Topics
- Adult
- Aged
- Carcinoma, Hepatocellular
- Enhancer Elements, Genetic
- Female
- Genotype
- Humans
- Liver Cirrhosis
- Liver Neoplasms
- Male
- Middle Aged
- Mutation
- Promoter Regions, Genetic
- Trans-Activators