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Article

X gene/core promoter deletion mutation: a novel mechanism leading to hepatitis B 'e' antigen‑negative chronic hepatitis B.

Molecular medicine reports - 1 Aug 2014

Zhou Fei, Xu Hongzhi, Chen Meiya, Xiao Hongmin, Zhang Zhiping, Lu Yapi, Ren Jianlin, Dong Jing

Abstract excerpt

Mutations in the precore and core promoter regions of hepatitis B 'e' antigen (HBeAg) are implicated in HBeAg‑negative chronic hepatitis B virus (HBV) infection (CHB). The objective of the current study was to investigate novel mutant patterns that lead to HBeAg‑negative CHB. The . PreX-X genomic region from the sera of HBV‑infected patients was amplified, and analysis of the sequences displayed a unique deletion...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B e Antigens

Share to Hepatitis B virus

Share to Promoter Regions, Genetic

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Share to Viral Regulatory and Accessory Proteins

Source

Identifiers

PMID: 24841504
DOI: 10.3892/mmr.2014.2248

Genes

CPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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