Article
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis.
The Journal of clinical investigation - 1 Sept 2000
Halangk W, Lerch M M, Brandt-Nedelev B, Roth W, Ruthenbuerger M, Reinheckel T, Domschke W, Lippert H, Peters C, Deussing J
Abstract excerpt
Autodigestion of the pancreas by its own prematurely activated digestive proteases is thought to be an important event in the onset of acute pancreatitis. The mechanism responsible for the intrapancreatic activation of digestive zymogens is unknown, but a recent hypothesis predicts that a redistribution of lysosomal cathepsin B (CTSB) into a zymogen-containing subcellular compartment triggers this event. To test...
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