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Article

Cathepsin B cleavage of the trypsinogen activation peptide.

BMC gastroenterology - 27 Jun 2002

Teich Niels, Bödeker Hans, Keim Volker

Abstract excerpt

BACKGROUND: Cathepsin B is thought to play a central role in intrapancreatic trypsinogen activation and the onset of pancreatitis. A recent investigation of the cathepsin B mediated activability of wildtype trypsinogen and their mutations N29I, N29T and R122H, which are associated to hereditary pancreatitis, revealed no differences. This action seems to be restricted to the K23-I24 peptide bond, which is the...

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Identifiers

PMID: 12102727
DOI: 10.1186/1471-230x-2-16
PMCID: PMC117221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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