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Article

Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice.

Gut - 1 Jun 2012

Gopinathan Aarthi, Denicola Gina M, Frese Kristopher K, Cook Natalie, Karreth Florian A, Mayerle Julia, Lerch Markus M, Reinheckel Thomas, Tuveson David A

Abstract excerpt

OBJECTIVE: The lysosomal protease cathepsin B is upregulated in human pancreatic ductal adenocarcinoma (PDA) and represents a potential therapeutic target. Loss of cathepsin B delays tumour progression in mouse models of islet, mammary and intestinal carcinoma and decreases invasion and metastasi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22157328
DOI: 10.1136/gutjnl-2011-300850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22157328-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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