Trypsin in pancreatitis: The culprit, a mediator, or epiphenomenon?

Abstract excerpt

Pancreatitis is a common, life-threatening inflammatory disease of the exocrine pancreas. Its pathogenesis remains obscure, and no specific or effective treatment is available. Gallstones and alcohol excess are major etiologies of pancreatitis; in a small portion of patients the disease is hereditary. Pancreatitis is believed to be initiated by injured acinar cells (the main exocrine pancreas cell type), leading...

Topics

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• Acinar Cells
• Disease Models, Animal
• Enzyme Activation
• Mice
• Pancreas