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Article

Absence of α-Syntrophin Leads to Structurally Aberrant Neuromuscular Synapses Deficient in Utrophin

18 Sept 2000

Abstract excerpt

The syntrophins are a family of structurally related proteins that contain multiple protein interaction motifs. Syntrophins associate directly with dystrophin, the product of the Duchenne muscular dystrophy locus, and its homologues. We have generated alpha-syntrophin null mice by targeted gene disruption to test the function of this association. The alpha-Syn(-/)- mice show no evidence of myopathy, despite...

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PMID: 10995443
DOI: 10.1083/jcb.150.6.1385

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Absence of α-Syntrophin Leads to Structurally Aberrant Neuromuscular Synapses Deficient in UtrophinPMID 10995443Read ↗

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