Article
Postsynaptic abnormalities at the neuromuscular junctions of utrophin-deficient mice.
The Journal of cell biology - 24 Feb 1997
Deconinck A E, Potter A C, Tinsley J M, Wood S J, Vater R, Young C, Metzinger L, Vincent A, Slater C R, Davies K E
Abstract excerpt
Utrophin is a dystrophin-related cytoskeletal protein expressed in many tissues. It is thought to link F-actin in the internal cytoskeleton to a transmembrane protein complex similar to the dystrophin protein complex (DPC). At the adult neuromuscular junction (NMJ), utrophin is precisely colocalized with acetylcholine receptors (AChRs) and recent studies have suggested a role for utrophin in AChR cluster...
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