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Article

Myopathic changes in murine skeletal muscle lacking synemin.

American journal of physiology. Cell physiology - 15 Mar 2015

García-Pelagio Karla P, Muriel Joaquin, O'Neill Andrea, Desmond Patrick F, Lovering Richard M, Lund Linda, Bond Meredith, Bloch Robert J

Abstract excerpt

Diseases of striated muscle linked to intermediate filament (IF) proteins are associated with defects in the organization of the contractile apparatus and its links to costameres, which connect the sarcomeres to the cell membrane. Here we study the role in skeletal muscle of synemin, a type IV IF protein, by examining mice null for synemin (synm-null). Synm-null mice have a mild skeletal muscle phenotype....

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Source

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Identifiers

PMID: 25567810
DOI: 10.1152/ajpcell.00331.2014
PMCID: PMC4360028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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