Article
Unique features of HIV-1 Rev protein phosphorylation by protein kinase CK2 ('casein kinase-2').
FEBS letters - 8 Sept 2000
Marin O, Sarno S, Boschetti M, Pagano M A, Meggio F, Ciminale V, D'Agostino D M, Pinna L A
Abstract excerpt
The HIV-1 Rev transactivator is phosphorylated in vitro by protein kinase CK2 at two residues, Ser-5 and Ser-8; these sites are also phosphorylated in vivo. Here we show that the mechanism by which CK2 phosphorylates Rev is unique in several respects, notably: (i) it is fully dependent on the regulatory, beta-subunit of CK2; (ii) it relies on the integrity of an acidic stretch of CK2 beta which down-regulates the...
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