Article
Casein Kinase II phosphorylation-induced conformational switch triggers degradation of the papillomavirus E2 protein.
The Journal of biological chemistry - 21 May 2004
Penrose Kerri J, Garcia-Alai Maria, de Prat-Gay Gonzalo, McBride Alison A
Abstract excerpt
The major phosphorylation sites of the bovine papillomavirus E2 transactivator protein are two serine residues, 298 and 301, that are located in a flexible hinge region between the DNA binding and transactivation domains. Phosphorylation of serine residue 301 promotes ubiquitination and rapid degradation of the E2 protein by the proteasome pathway. To understand the mechanism through which phosphorylation...
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