Article
High interleukin-10 production in first-degree relatives of patients with generalized but not cutaneous lupus erythematosus.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Sept 2000
van der Linden M W, Westendorp R G, Sturk A, Bergman W, Huizinga T W
Abstract excerpt
BACKGROUND: Preclinical research suggests that interleukin-10 (IL-10) is associated with susceptibility to and severity of systemic lupus erythematosus. Chronic cutaneous lupus erythematosus is thought to be immunogenetically different from systemic lupus erythematosus. We hypothesized that high innate production of IL-10 underlies systemic but not chronic cutaneous lupus erythematosus. METHODS: IL-10 production...
Topics
- Adult
- Cells, Cultured
- DNA
- DNA Primers
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Interleukin-10
- Lupus Erythematosus, Cutaneous
- Lupus Erythematosus, Systemic
- Lymphocyte Activation