Article
Role of interleukin-10 and interleukin-10 receptor in systemic lupus erythematosus.
Clinical rheumatology - 1 Sept 2013
Peng Hui, Wang Wei, Zhou Mo, Li Rui, Pan Hai-Feng, Ye Dong-Qing
Abstract excerpt
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by excessive production of a variety of autoantibodies, accumulation of immune complexes, and multiple organ systems involvement. Interleukin-10 (IL-10) has an important role in the growth, survival, differentiation, and function of B cells. Abnormally increased IL-10 synthesis seems contributing to the spontaneous hyperactivity...
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