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Article

Proximal interleukin-10 gene polymorphisms in Italian patients with systemic sclerosis.

Tissue antigens - 1 Apr 2007

Beretta L, Cappiello F, Barili M, Scorza R

Abstract excerpt

Interleukin-10 (IL-10) can favour the development of fibrosis by promoting a relative shift towards T helper 2 responses. Three single base pair substitutions in the 5' flanking region of the IL-10 gene (G/A -1082, C/T -819 and C/A -592) influence the amount of IL-10 secreted in cell cultures: the GCC haplotype is associated with an increased production, while the ACC and the ATA haplotypes are associated with...

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Identifiers

PMID: 17389013
DOI: 10.1111/j.1399-0039.2007.00811.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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