Article
PTEN expression in melanoma: relationship with patient survival, Bcl-2 expression, and proliferation.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2005
Mikhail Maryann, Velazquez Elsa, Shapiro Richard, Berman Russell, Pavlick Anna, Sorhaindo Lian, Spira Joanna, Mir Carmen, Panageas Katherine S, Polsky David, Osman Iman
Abstract excerpt
PURPOSE: Inactivation of the tumor suppressor gene, phosphatase and tensin homologue (PTEN), is a major alteration in preclinical melanoma models. We investigated the clinical relevance of PTEN expression in the primary melanoma patients with extended follow-up. EXPERIMENTAL DESIGN: We correlated PTEN expression with clinicopathologic variables and outcome in 127 primary melanomas (median follow-up, 12.8 years)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.