Article
Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2014
Bucheit Amanda D, Chen Guo, Siroy Alan, Tetzlaff Michael, Broaddus Russell, Milton Denai, Fox Patricia, Bassett Roland, Hwu Patrick, Gershenwald Jeffrey E, Lazar Alexander J, Davies Michael A
Abstract excerpt
PURPOSE: Loss of function of PTEN is a frequent event in melanoma, particularly in tumors with BRAF(V600) mutations. The prevalence, pathologic features, and clinical outcomes associated with PTEN loss in patients with stage IIIB/C melanoma were interrogated to improve our understanding of the clinical significance of this molecular event. EXPERIMENTAL DESIGN: Archival tissue from lymphadenectomy specimens among...
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