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Article

IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2000

Shi F D, Takeda K, Akira S, Sarvetnick N, Ljunggren H G

Abstract excerpt

IL-18 promotes NK cell and Th1 cell activity and may bridge innate and adaptive immune responses. Myelin oligodendrocyte glycoprotein (MOG) is a myelin component of the CNS and is a candidate autoantigen in multiple sclerosis. In the present study we show that IL-18-deficient (IL-18-/-) mice are defective in mounting autoreactive Th1 and autoantibody responses and are resistant to MOG35-55 peptide-induced...

Read the complete abstract on PubMed

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Share to Autoantigens
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Interleukin-18

Share to Myelin-Associated Glycoprotein

Share to Myelin-Oligodendrocyte Glycoprotein

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Share to Th1 Cells

Source

Identifiers

PMID: 10975822
DOI: 10.4049/jimmunol.165.6.3099

Genes

MOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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