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Article

Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2011

Lalor Stephen J, Dungan Lara S, Sutton Caroline E, Basdeo Sharee A, Fletcher Jean M, Mills Kingston H G

Abstract excerpt

IL-1β plays a critical role in promoting IL-17 production by γδ and CD4 T cells. However, IL-1-targeted drugs, although effective against autoinflammatory diseases, are less effective against autoimmune diseases. Conversely, gain-of-function mutations in the NLRP3 inflammasome complex are associated with enhanced IL-1β and IL-18 production and Th17 responses. In this study, we examined the role of...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, gamma-delta

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Identifiers

PMID: 21471445
DOI: 10.4049/jimmunol.1003597

Genes

NLRP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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