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Article

Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2000

Pien G C, Satoskar A R, Takeda K, Akira S, Biron C A

Abstract excerpt

Optimal protective effects for defense against infection require orchestration of immune responses spanning multiple host compartments and divergent local regulation at particular sites. During murine cytomegalovirus infections known to target spleen and liver, IL-12-induced IFN-gamma from NK cells is crucial for resistance. However, the roles for IL-18 and/or IL-12 in regulating hepatic IFN-gamma responses, as...

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Source

Identifiers

PMID: 11046000
DOI: 10.4049/jimmunol.165.9.4787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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