Article
Genetic variation in in-vitro cytokine-induced production of nitric oxide by murine peritoneal macrophages.
Pharmacogenetics - 1 Aug 2000
Zídek Z, Franková D, Boubelík M
Abstract excerpt
Quantitative aspects of the in-vitro interferon (IFN)-gamma-induced nitric oxide (NO) production by peritoneal macrophages of eight inbred strains of mice were investigated. Animals employed in the study can be assorted into three phenotype categories: high, moderate, and low NO-responders. Concentration of nitrites in the 24-h supernatants of cells stimulated with recombinant murine IFN-gamma (25 U/ml) reached...
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