Article
Strain difference in the induction of T-cell activation-associated, interferon gamma-dependent hepatic injury in mice.
Hepatology (Baltimore, Md.) - 1 Feb 1998
Mizuhara H, Kuno M, Seki N, Yu W G, Yamaoka M, Yamashita M, Ogawa T, Kaneda K, Fujii T, Senoh H, Fujiwara H
Abstract excerpt
A single intravenous injection of concanavalin A (Con A) induces T-cell activation-associated inflammatory injury selectively in the liver. This study investigated the strain difference in the development of Con A-induced hepatic injury. Normal C57BL/6 and BALB/c spleen cells produced comparable levels of T-cell-derived lymphokines (interferon gamma [IFN-gamma], tumor necrosis factor alpha [TNF-alpha], and...
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