Article
Mouse genotype affects inducible expression of cytokine genes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1992
Raj N B, Cheung S C, Rosztoczy I, Pitha P M
Abstract excerpt
The levels of circulating IFN in mice infected with Newcastle disease virus (NDV) are regulated by the If-1 locus. In this study we show that in NDV-infected C57BL/6 mice, which carry the If-1h allele and produce high levels of IFN, high levels of both IFN-alpha and -beta mRNA can be detected in the spleen. In contrast, only very low levels of IFN mRNA could be detected in spleens of infected BALB/c mice...
Topics
- Animals
- Cytokines
- Gene Expression
- Genes, Regulator
- Genotype
- Interferons
- Mice
- Mice, Inbred Strains
- Newcastle Disease
- Newcastle disease virus
- Peritoneal Cavity
- RNA, Messenger