Article
A defective TLR4 signaling for IFN-β expression is responsible for the innately lower ability of BALB/c macrophages to produce NO in response to LPS as compared to C57BL/6.
PloS one - 1 Jan 2014
Oliveira Luciana S, de Queiroz Nina M G P, Veloso Laura V S, Moreira Thaís G, Oliveira Fernanda S, Carneiro Matheus B H, Faria Ana M, Vieira Leda Q, Oliveira Sérgio C, Horta Maria F
Abstract excerpt
C57BL/6 mice macrophages innately produce higher levels of NO than BALB/c cells when stimulated with LPS. Here, we investigated the molecular events that account for this intrinsic differential production of NO. We found that the lower production of NO in BALB/c is not due to a subtraction of L-arginine by arginase, and correlates with a lower iNOS accumulation, which is independent of its degradation rate....
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