Article
CYP2D6 ultrarapid metabolizer genotype as a potential modifier of smoking behaviour.
Pharmacogenetics - 1 Feb 2000
Saarikoski S T, Sata F, Husgafvel-Pursiainen K, Rautalahti M, Haukka J, Impivaara O, Järvisalo J, Vainio H, Hirvonen A
Abstract excerpt
Some 3-10% of Caucasians are deficient in CYP2D6 metabolism (poor metabolizers), due to inheritance of two defective alleles, whereas amplification of the CYP2D6 gene results in ultrarapid metabolism in 1-2% of Caucasian populations. To examine the possible association between CYP2D6 polymorphism and individual smoking behaviour, we analysed the prevalence of CYP2D6 genotypes among 292 long-term heavy smokers,...
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