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Article

Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma

5 Sept 2000

Abstract excerpt

Immune surveillance by cytotoxic lymphocytes against cancer has been postulated for decades, but direct evidence for the role of cytotoxic lymphocytes in protecting against spontaneous malignancy has been lacking. As the rejection of many experimental cancers by cytotoxic T lymphocytes and natural killer cells is dependent on the pore-forming protein perforin (pfp), we examined pfp-deficient mice for increased...

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Identifiers

PMID: 10974040
DOI: 10.1084/jem.192.5.755

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