Article
A proportion of patients with lymphoma may harbor mutations of the perforin gene.
Blood - 1 Jun 2005
Clementi Rita, Locatelli Franco, Dupré Loïc, Garaventa Alberto, Emmi Lorenzo, Bregni Marco, Cefalo Graziella, Moretta Antonia, Danesino Cesare, Comis Margherita, Pession Andrea, Ramenghi Ugo, Maccario Rita, Aricò Maurizio, Roncarolo Maria Grazia
Abstract excerpt
Perforin mutations have been demonstrated in a proportion of patients diagnosed with the familial form of hemophagocytic lymphohistiocytosis (HLH). In the present study, we evaluated whether some patients with lymphoma sharing clinical characteristics with HLH might harbor mutations of the perforin gene. We analyzed 29 patients and found that 4 patients, who developed either Hodgkin or non-Hodgkin lymphoma, had...
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