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Delayed kinetics of DNA double‐strand break processing in normal and pathological aging

13 Nov 2007

Abstract excerpt

Accumulation of DNA damage may play an essential role in both cellular senescence and organismal aging. The ability of cells to sense and repair DNA damage declines with age. However, the underlying molecular mechanism for this age-dependent decline is still elusive. To understand quantitative and qualitative changes in the DNA damage response during human aging, DNA damage-induced foci of phosphorylated histone...

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PMID: 18005250
DOI: 10.1111/j.1474-9726.2007.00354.x

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