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Copy Number of Human Ribosomal Genes With Aging: Unchanged Mean, but Narrowed Range and Decreased Variance in Elderly Group

7 Aug 2018

Abstract excerpt

Introduction. The multi-copied genes coding for the human 18S, 5.8S and 28S ribosomal RNA (rRNA) are located in five pairs of acrocentric chromosomes forming so-called rDNA. Human genome contains unmethylated, slightly methylated and hypermethylated copies of rDNA. The major research question: What is the rDNA copy number (rDNA CN) and the content of hypermethylated rDNA as a function of age? Materials and...

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PMID: 30131826
DOI: 10.3389/fgene.2018.00306

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