Article
Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1.
Nature medicine - 1 Sept 2000
Jochum W, David J P, Elliott C, Wutz A, Plenk H, Matsuo K, Wagner E F
Abstract excerpt
Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts....
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