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Article

Fra-1 potentiates osteoclastic differentiation in osteoclast-macrophage precursor cell lines.

Journal of cellular physiology - 1 May 1999

Owens J M, Matsuo K, Nicholson G C, Wagner E F, Chambers T J

Abstract excerpt

c-Fos, a component of the dimeric transcription factor AP-1, is necessary for osteoclast formation. To determine whether c-Fos can substitute for any or all of the stimuli needed for osteoclast induction, we infected osteoclast precursors with retroviral vectors expressing c-Fos or the Fos-related protein, Fra-1. The infected cells were incubated with or without osteoclast-inductive stimuli. Osteoclast formation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10199556
DOI: 10.1002/(SICI)1097-4652(199905)179:2<170::AID-JCP7>3.0.CO;2-K

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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