Article
Increased frequency of G-protein beta 3-subunit 825 T allele in dialyzed patients with type 2 diabetes.
Kidney international - 1 Apr 1999
Blüthner M, Schmidt S, Siffert W, Knigge H, Nawroth P, Ritz E
Abstract excerpt
BACKGROUND: A polymorphism (C825T) in exon 10 of the gene encoding the beta 3 subunit of heterotrimeric G proteins (GN beta 3) has recently been described, and the T allele was found to be associated with late-onset hypertension. Because hypertension is a known risk factor for the development of clinically manifest progressive renal disease, we examined the C825T polymorphism in older hemodialysis patients...
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