Article
Strand bias in Ig somatic hypermutation is determined by signal sequence within the variable region.
International immunology - 1 Sept 2000
Ching A K, Li P S, Chan W Y, Ma C H, Lee S S, Lim P L, Chui Y L
Abstract excerpt
Ig genes undergo hypermutation with a nucleotide preference of A over T for mutation on the coding strand. As only with concomitant strand bias can such nucleotide bias be observed, Ig gene hypermutation is generally accepted as a strand-specific process, for which the mechanistic basis remains u...
Topics
- Animals
- B-Lymphocytes
- Bacterial Proteins
- DNA Mutational Analysis
- DNA Primers
- Escherichia coli Proteins
- Female
- Immunoglobulin Joining Region
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Mutation