Article
Strand bias in Ig somatic hypermutation is determined by signal sequence within the variable region.
International immunology - 1 Sept 2000
Ching A K, Li P S, Chan W Y, Ma C H, Lee S S, Lim P L, Chui Y L
Abstract excerpt
Ig genes undergo hypermutation with a nucleotide preference of A over T for mutation on the coding strand. As only with concomitant strand bias can such nucleotide bias be observed, Ig gene hypermutation is generally accepted as a strand-specific process, for which the mechanistic basis remains unknown. It has previously been shown that different non-Ig sequences replacing the LVJ region of an Ig transgene to...
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