Article
On the functional importance of thyrotropin receptor intramolecular cleavage.
Endocrinology - 1 Oct 1999
Chazenbalk G D, Tanaka K, McLachlan S M, Rapoport B
Abstract excerpt
We examined the relationship between TSH receptor (TSHR) cleavage into two subunits and ligand-independent, constitutive activity characteristic of this receptor. Because of homology to the thrombin receptor-tethered ligand, we focused initially on a region in the vicinity of the second, downstream cleavage site of the TSHR ectodomain. We introduced into the wild-type TSHR three mutations. One mutation,...
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