Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells.

Oncogene - 3 Sept 2009

Komlodi-Pasztor E, Trostel S, Sackett D, Poruchynsky M, Fojo T

Abstract excerpt

Previous studies have described one nuclear localization signal (NLSI) in p53 and speculated on two additional sites termed NLSII and NLSIII. Drug-resistant KB cells selected with cisplatin or oxaliplatin were found to have increased p53 levels and in oxaliplatin-selected cells, a larger p53 predominantly in the cytoplasm. In oxaliplatin-selected cells a single nucleotide deletion in the sequence-encoding amino...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Karyopherins
Share to Biological Transport, Active

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Drug Resistance, Neoplasm

Share to Frameshift Mutation

Share to Inhibitory Concentration 50

Share to Organoplatinum Compounds

Share to Oxaliplatin

Source

Open in PubMed Open full text

Identifiers

PMID: 19581934
DOI: 10.1038/onc.2009.166
PMCID: PMC2867326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells.PMID 19581934Read ↗

Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptideSemantic proximity Read ↗

Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination.Semantic proximity Read ↗

A minimal nuclear localization signal (NLS) in human phospholipid scramblase 4 that binds only the minor NLS-binding site of importin alpha1.Semantic proximity Read ↗

ALADINI482S causes selective failure of nuclear protein import and hypersensitivity to oxidative stress in triple A syndrome.Semantic proximity Read ↗

Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination.Semantic proximity Read ↗

Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein.Semantic proximity Read ↗

Defective nuclear localization of p53 protein in a Chinese hamster cell line is associated with the formation of stable cytoplasmic protein multimers in cells with gene amplification.Semantic proximity Read ↗

p53-dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage.Semantic proximity Read ↗

DNA polymerase β contains a functional nuclear localization signal at its N-terminus.Semantic proximity Read ↗

Cytoplasmic Sequestration of Wild-Type p53 Protein Impairs the G 1 Checkpoint after DNA DamageSemantic proximity Read ↗

Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.Semantic proximity Read ↗

Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.