Article
The molecular biology of Fanconi anemia.
The Israel Medical Association journal : IMAJ - 1 Oct 2002
Tamary Hannah, Bar-Yam Raanan, Zemach Michal, Dgany Orly, Shalmon Lea, Yaniv Isaac
Abstract excerpt
Fanconi anemia is a rare autosomal recessive disorder characterized clinically by congenital abnormalities, progressive bone marrow failure, and a predisposition to malignancy. FA cells are sensitive to DNA cross-linking agents. Complementation analysis of FA cells using somatic cell fusion has facilitated the identification of eight complementation groups, suggesting that FA is a genetically heterogeneous...
Topics
- Adolescent
- Adult
- Anemia, Aplastic
- Animals
- Apoptosis
- Cell Fusion
- Cell Line
- Cloning, Molecular
- DNA Repair
- Disease Models, Animal
- Ethnicity
- Fanconi Anemia
- Forecasting
- Genes, BRCA1
- Genetic Complementation Test
- Genetic Research
- Genotype
- Humans