Article
Epigenetic and genotype-specific effects on the stability of de novo imposed methylation patterns in transgenic mice.
The Journal of biological chemistry - 1 Dec 2000
Schumacher A, Koetsier P A, Hertz J, Doerfler W
Abstract excerpt
The chloramphenicol acetyltransferase gene under the control of the late E2A promoter of adenovirus type 2 (Ad2) was introduced as transgene into the B6D2F1 mouse strain with mixed genetic background and became extensively de novo methylated. The methylation of this pAd2E2AL-CAT (7-1A) transgene was regulated in a strain-specific manner apparently depending on the site of integration. Transmission of the 7-1A...
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