Epigenetic control of transgene expression and imprinting by genotype-specific modifiers.

doi:10.1016/0092-8674(90)90195-k

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Article

Epigenetic control of transgene expression and imprinting by genotype-specific modifiers.

Cell - 1 Jun 1990

Allen N D, Norris M L, Surani M A

Abstract excerpt

Expression and DNA methylation of the transgene locus TKZ751 are controlled by genotype-specific modifier genes. The DBA/2 and 129 genetic backgrounds enhanced expression, while the BALB/c background suppressed expression, but only following maternal inheritance of the BALB/c modifier. Epigenetic...

Topics

Animals
DNA
Gene Expression Regulation
Genotype
Methylation
Mice
Mice, Inbred BALB C
Mice, Inbred DBA
Mice, Transgenic
Phenotype
beta-Galactosidase

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