Article
Relationship between retroviral DNA integration and gene expression.
Journal of virology - 1 Sept 2000
Weidhaas J B, Angelichio E L, Fenner S, Coffin J M
Abstract excerpt
Although retroviruses can integrate their DNA into a large number of sites in the host genome, factors controlling the specificity of integration remain controversial and poorly understood. To assess the effects of transcriptional activity on integration in vivo, we created quail cell clones containing a construct with a minigene cassette, whose expression is controlled by the papilloma virus E2 protein. From...
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