Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis.

doi:10.1038/307241a0

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Article

Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis.

Nature - 1 Jan 2000

Cullen B R, Lomedico P T, Ju G

Abstract excerpt

The downstream (3') long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5') LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have b...

Topics

Animals
Cell Transformation, Viral
Chickens
Gene Expression Regulation
Insulin
Leukemia, Experimental
Mutation
Oncogenes
Operon
Repetitive Sequences, Nucleic Acid
Retroviridae
Transcription, Genetic
Viral Envelope Proteins

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