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Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration

16 Jul 2004

Abstract excerpt

Integrated hepadnaviral DNA in livers and tumors of chronic hepatitis B patients has been reported for many years. In this study, we investigated whether hepatitis B virus DNA integration occurs preferentially at sites of cell DNA damage. A single I-SceI homing endonuclease recognition site was introduced into the DNA of the chicken hepatoma cell line LMH by stable DNA transfection, and double-strand breaks were...

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PMID: 15258290
DOI: 10.1073/pnas.0403925101

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