Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential.

Gene expression - 1 Jan 1999

Kumar M B, Perdew G H

Abstract excerpt

The aryl hydrocarbon receptor (AhR), a soluble cytosolic protein, mediates many of the toxic effects of TCDD and related chemicals. The toxic effects are largely cell, tissue, and promoter context dependent. Although many details of the overall dioxin signal transduction have been elucidated, the transcriptional regulation of dioxin-induced genes like cyp1A1 is not yet completely understood. Previously, we have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Aryl Hydrocarbon Receptor Nuclear Translocator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COS Cells

Share to Histone Acetyltransferases

Share to Luminescent Proteins

Share to Nuclear Receptor Coactivator 1

Share to Polychlorinated Dibenzodioxins

Share to Receptors, Aryl Hydrocarbon

Source

Open in PubMed Open full text

Identifiers

PMID: 10947077
PMCID: PMC6157383

Genes

SRC
ARNT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential.PMID 10947077Read ↗

Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1.Semantic proximity Read ↗

The Function of Steroid Receptor Coactivator-1 in Normal Tissues and CancerSemantic proximity Read ↗

The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesisSemantic proximity Read ↗

Aryl hydrocarbon receptor SNP -130 C/T associates with dioxins susceptibility through regulating its receptor activity and downstream effectors including interleukin 24.Semantic proximity Read ↗

Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings.Semantic proximity Read ↗

Differential gene regulation by the SRC family of coactivators.Semantic proximity Read ↗

The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).Semantic proximity Read ↗

Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines.Semantic proximity Read ↗

Organization and function of a dioxin-responsive enhancer.Semantic proximity Read ↗

Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system.Semantic proximity Read ↗

The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin.Semantic proximity Read ↗

Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.