Article
Aryl hydrocarbon receptor SNP -130 C/T associates with dioxins susceptibility through regulating its receptor activity and downstream effectors including interleukin 24.
Toxicology letters - 22 Jan 2015
Liu Ge, Asanoma Kazuo, Takao Tomoka, Tsukimori Kiyomi, Uchi Hiroshi, Furue Masutaka, Kato Kiyoko, Wake Norio
Abstract excerpt
Dioxins are persistent environmental pollutants that cause multiple adverse health effects in humans, mainly through binding to the ligand-activated transcription factor, aryl hydrocarbon receptor (AhR). Genetic variation in AhR may modulate the susceptibility to dioxins. In this study, we aimed to evaluate the effects of the single nucleotide polymorphism (SNP) -130 C/T in the AhR promoter on dioxin-inducible...
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