The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin.

doi:10.1210/me.2007-0128

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin.

Molecular endocrinology (Baltimore, Md.) - 1 Feb 2008

Rüegg Joëlle, Swedenborg Elin, Wahlström David, Escande Aurelie, Balaguer Patrick, Pettersson Katarina, Pongratz Ingemar

Abstract excerpt

The biological effects of dioxins are mediated by the aryl hydrocarbon receptor (AhR) and its dimerization partner, the AhR nuclear translocator (ARNT), and include interference with hormonal signaling pathways like the response to estrogens. The effects of estrogens are mediated by two estrogen receptor (ER) isoforms, ERalpha and ERbeta, which belong to the family of nuclear receptors. We have previously shown...

Topics

Animals
Aryl Hydrocarbon Receptor Nuclear Translocator
Cell Hypoxia
Cell Line
Cell Line, Tumor
Chromatin Immunoprecipitation
Dimerization
Dioxins
Estradiol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Estrogen Receptor alpha

Estrogen Receptor beta

HeLa Cells

Humans

Hypoxia-Inducible Factor 1, alpha Subunit

Models, Biological

Mutation

Polychlorinated Dibenzodioxins

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 17991765
DOI: 10.1210/me.2007-0128
PMCID: PMC5419643

Genes

ARNT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin.PMID 17991765Read ↗

Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings.Semantic proximity Read ↗

Gene-environment interactions in male reproductive health: special reference to the aryl hydrocarbon receptor signaling pathway.Semantic proximity Read ↗

Dynamic relationship between the aryl hydrocarbon receptor and long noncoding RNA balances cellular and toxicological responsesSemantic proximity Read ↗

Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines.Semantic proximity Read ↗

Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.Semantic proximity Read ↗

Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system.Semantic proximity Read ↗

Definition of a dioxin receptor mutant that is a constitutive activator of transcription: delineation of overlapping repression and ligand binding functions within the PAS domain.Semantic proximity Read ↗

The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.Semantic proximity Read ↗

Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction.Semantic proximity Read ↗

Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer DevelopmentSemantic proximity Read ↗

Resveratrol and 3,3’-diindolylmethane differentially regulate aryl hydrocarbon receptor and estrogen receptor alpha to modulate diverse signalling pathways in MCF-7 human breast cancer cellsSemantic proximity Read ↗

Dioxin toxicity in vivo results from an increase in the dioxin-independent transcriptional activity of the aryl hydrocarbon receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.