Article
Variable region diversity of the Atlantic cod (Gadus morhua L.) immunoglobulin heavy chain.
Immunogenetics - 1 Jul 2000
Stenvik J, Lundbäck A S, Jørgensen T O, Pilström L
Abstract excerpt
This study was undertaken to determine whether a lack of VH domain diversity could explain, in part, the failure of Atlantic cod to respond to immunization with the production of specific antibodies. The variability of cod VH regions was studied in 113 cDNA and 2 genomic clones. A fourth VH family and a second putative JH element were identified. The expressed VH repertoire showed a clear bias in the pattern of...
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