Article
Light chain variable region diversity in Atlantic cod (Gadus morhua L.).
Developmental and comparative immunology - 1 Apr 1999
Widholm H, Lundbäck A S, Daggfeldt A, Magnadottir B, Warr G W, Pilström L
Abstract excerpt
This study was undertaken to determine if a lack of V(L) domain variability could explain, in part, the failure of Atlantic cod to respond to immunization with the production of specific antibodies. The variability of cod V(L) regions was studied in 33 cDNA and two genomic clones. The variability of the CDRs was estimated by the Shannon entropy method and compared with that in other species. It was found to be...
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