Article
Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jul 2003
Souza D R S, de Godoy M R, Hotta J, Tajara E H, Brandão A C, Pinheiro Júnior S, Tognola W A, dos Santos J E
Abstract excerpt
The genetic basis for dementias is complex. A common polymorphism in the apolipoprotein E (APOE) gene is considered to be the major risk factor in families with sporadic and late-onset Alzheimer's disease as well as in the general population. The distribution of alleles and genotypes of the APOE gene in late-onset Alzheimer's disease (N = 68), other late-life dementias (N = 39), and in cognitively normal controls...
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