Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Xotx5b, a new member of the Otx gene family, may be involved in anterior and eye development in Xenopus laevis.

Mechanisms of development - 1 Aug 2000

Vignali R, Colombetti S, Lupo G, Zhang W, Stachel S, Harland R M, Barsacchi G

Abstract excerpt

We describe the cloning, expression pattern and functional overexpression analysis of Xotx5b, a new member of the Otx gene family in Xenopus laevis. Early expression of Xotx5b resembles that of Xotx2, being detected in the organizer region at early gastrula stage, and, shortly after, also in anterior neuroectoderm. During neurula stages Xotx5b exhibits a changing and dynamic pattern of expression. After neural...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eye
Share to Gastrula
Share to Gene Library

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neural Crest

Share to Otx Transcription Factors

Share to Tissue Distribution

Share to Xenopus

Share to Xenopus Proteins

Source

Identifiers

PMID: 10940620
DOI: 10.1016/s0925-4773(00)00367-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Xotx5b, a new member of the Otx gene family, may be involved in anterior and eye development in Xenopus laevis.PMID 10940620Read ↗

A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina.Semantic proximity Read ↗

The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions.Semantic proximity Read ↗

Anteroposterior patterning by mutual repression of orthodenticle and caudal-type transcription factors.Semantic proximity Read ↗

Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm.Semantic proximity Read ↗

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.Semantic proximity Read ↗

The homeobox gene Otx2 in development and diseaseSemantic proximity Read ↗

FGF8, Wnt8 and Myf5 are target genes of Tbx6 during anteroposterior specification in Xenopus embryo.Semantic proximity Read ↗

OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.Semantic proximity Read ↗

Canonical Wnt signaling modulates <i>Tbx1</i>, <i>Eya1</i>, and <i>Six1</i> expression, restricting neurogenesis in the otic vesicleSemantic proximity Read ↗

oto is a homeotic locus with a role in anteroposterior development that is partially redundant with Lim1.Semantic proximity Read ↗

Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.Semantic proximity Read ↗

OTX2 activates the molecular network underlying retina pigment epithelium differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.