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Article

OTX2 activates the molecular network underlying retina pigment epithelium differentiation.

The Journal of biological chemistry - 13 Jun 2003

Martínez-Morales Juan Ramón, Dolez Vincent, Rodrigo Isabel, Zaccarini Raffaella, Leconte Laurence, Bovolenta Paola, Saule Simon

Abstract excerpt

The retina pigment epithelium (RPE) is fundamental for the development and function of the vertebrate eye. Molecularly, the presumptive RPE can be identified by the early expression of two transcription factors, Mitf and Otx. In mice deficient for either gene, RPE development is impaired with loss of melanogenic gene expression, raising the possibility that in the eye OTX proteins operate either in a feedback...

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Source

Identifiers

PMID: 12663655
DOI: 10.1074/jbc.M301708200

Genes

RPE
OTX2
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

OTX2 activates the molecular network underlying retina pigment epithelium differentiation.PMID 12663655Read ↗

Otx but not Mitf transcription factors are required for zebrafish retinal pigment epithelium development.Semantic proximity Read ↗

Analysis of Transcriptional Regulatory Pathways of Photoreceptor Genes by Expression Profiling of the Otx2-Deficient RetinaSemantic proximity Read ↗

Otx2 and Oc1 directly regulate the transcriptional program of cone photoreceptor developmentSemantic proximity Read ↗

Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell DevelopmentSemantic proximity Read ↗

Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding site.Semantic proximity Read ↗

Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression.Semantic proximity Read ↗

OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification.Semantic proximity Read ↗

The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degenerationSemantic proximity Read ↗

Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration.Semantic proximity Read ↗

BEST1 expression in the retinal pigment epithelium is modulated by OTX family membersSemantic proximity Read ↗

Microphthalmia transcription factor induces both retinal pigmented epithelium and neural crest melanocytes from neuroretina cells.Semantic proximity Read ↗

OTX2 mutations cause autosomal dominant pattern dystrophy of the retinal pigment epithelium.Semantic proximity Read ↗

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