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Article

Anteroposterior patterning by mutual repression of orthodenticle and caudal-type transcription factors.

Evolution & development - 1 Jan 2000

Isaacs H V, Andreazzoli M, Slack J M

Abstract excerpt

Members of the Otx (orthodenticle) and Cdx (caudal) families of homeodomain transcription factors are expressed in similar embryonic regions in all animal groups and have been shown to be directly involved in anteroposterior patterning in a number of species. In the amphibian Xenopus laevis, the Otx family gene Xotx2 and the Cdx family gene Xcad3 are both expressed within the early dorsal organizer. We show that...

Topics

Animals
Body Patterning
Drosophila melanogaster
Embryo, Nonmammalian
In Situ Hybridization
Phenotype
Repressor Proteins
Trans-Activators
Transcription Factors
Xenopus laevis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11324099
DOI: 10.1046/j.1525-142x.1999.99020.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11324099-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Anteroposterior patterning by mutual repression of orthodenticle and caudal-type transcription factors.PMID 11324099Read ↗

The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions.Semantic proximity Read ↗

Calponin modulates the exclusion of Otx-expressing cells from convergence extension movements.Semantic proximity Read ↗

Patterning of the embryo along the anterior-posterior axis: the role of the caudal genes.Semantic proximity Read ↗

Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast.Semantic proximity Read ↗

Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm.Semantic proximity Read ↗

Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.Semantic proximity Read ↗

Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain.Semantic proximity Read ↗

Otx genes in the development and evolution of the vertebrate brain.Semantic proximity Read ↗

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.Semantic proximity Read ↗

Xotx5b, a new member of the Otx gene family, may be involved in anterior and eye development in Xenopus laevis.Semantic proximity Read ↗

Overlapping functions of Cdx1, Cdx2, and Cdx4 in the development of the amphibian Xenopus tropicalis.Semantic proximity Read ↗

Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation.Semantic proximity Read ↗

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