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Article

Anteroposterior patterning by mutual repression of orthodenticle and caudal-type transcription factors.

Evolution & development - 1 Jan 2000

Isaacs H V, Andreazzoli M, Slack J M

Abstract excerpt

Members of the Otx (orthodenticle) and Cdx (caudal) families of homeodomain transcription factors are expressed in similar embryonic regions in all animal groups and have been shown to be directly involved in anteroposterior patterning in a number of species. In the amphibian Xenopus laevis, the Otx family gene Xotx2 and the Cdx family gene Xcad3 are both expressed within the early dorsal organizer. We show that...

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Identifiers

PMID: 11324099
DOI: 10.1046/j.1525-142x.1999.99020.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Anteroposterior patterning by mutual repression of orthodenticle and caudal-type transcription factors.PMID 11324099Read ↗

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Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast.Semantic proximity Read ↗

Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm.Semantic proximity Read ↗

Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.Semantic proximity Read ↗

Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain.Semantic proximity Read ↗

Otx genes in the development and evolution of the vertebrate brain.Semantic proximity Read ↗

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.Semantic proximity Read ↗

Xotx5b, a new member of the Otx gene family, may be involved in anterior and eye development in Xenopus laevis.Semantic proximity Read ↗

Overlapping functions of Cdx1, Cdx2, and Cdx4 in the development of the amphibian Xenopus tropicalis.Semantic proximity Read ↗

Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation.Semantic proximity Read ↗

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