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Article

Oligomerization of the ABL Tyrosine Kinase by the Ets Protein TEL in Human Leukemia

1 Aug 1996

Abstract excerpt

TEL is a member of the Ets family of transcription factors which are frequently rearranged in human leukemia. The mechanism of TEL-mediated transformation, however, is unknown. We report the cloning and characterization of a chromosomal translocation associated with acute myeloid leukemia which fuses TEL to the ABL tyrosine kinase. The TEL-ABL fusion confers growth factor-independent growth to the marine...

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PMID: 8754809
DOI: 10.1128/mcb.16.8.4107

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